Ebooks News

Unraveling Tissue Regeneration Using Chemical Genetics

11 View(s), published at 2008, written by Lijoy K. Mathew, published by ProQuest
Unraveling Tissue Regeneration Using Chemical Genetics

Unraveling tissue regeneration using chemical genetics by Lijoy K. Mathew Understanding the advantages of chemicals to probe tissue regeneration, we developed a rapid throughput regeneration assay to identify additional small molecules that modulated regeneration. Glucocort.... Published date on: 2008 with total page: 200 pages. Publisher of Unraveling Tissue Regeneration Using Chemical Genetics is ProQuest.

Understanding the advantages of chemicals to probe tissue regeneration, we developed a rapid throughput regeneration assay to identify additional small molecules that modulated regeneration. Glucocorticoids were identified as inhibitors of regeneration and we demonstrated that glucocorticoid receptor activation is absolutely required for mediating the inhibition of regeneration. We further illustrated that, signaling from exogenous glucocorticoids impairs blastema formation and limits regenerative capability in vertebrates through an acute inflammation-independent mechanism and also report that, neutrophils and macrophages are not required for fin regeneration. Finally, we performed a comparative global genomic analysis between different zebrafish regeneration models and identified raldh2, a rate limiting enzyme for retinoic acid (RA) synthesis as a candidate gene across the distinct regeneration models. We demonstrated that, in addition to the well established role of RA signaling during the later phase of regenerative outgrowth, this signaling pathway is also critical for the initiation of regeneration, suggesting a dual phase of RA signaling during fin regeneration. Collectively, our results obtained through different experimental approaches suggest that, epimorphic regeneration is completed by a well orchestrated process of multiple molecular signaling events.

Do you want to subcribe this ebook unraveling tissue regeneration using chemical genetics? If you have read an ebook before don't be hasitate to leave review about the book unraveling tissue regeneration using chemical genetics. But otherwise, you can registar/sign up before downloding this pdf book. We have huge database of ebooks in our library. If you bought an ebook than you want another ebook we suggest you to become our library member.

What do you get from becoming member in our library? 1.You can read free a lot of books from our database. 2.You can use any kind of ebook reader available on market, because our book available in various format. 3.You able to find your ebook fastly through our library because we put ebooks based on categories such as adventure, art, law, social, health, medical, science, romance, fiction, non-fiction and etc.

Tags: