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Numerical Methods for the Life Scientist

6 View(s), published at 2011-08-06, written by Heino Prinz, published by Springer Science & Business Media
Numerical Methods for the Life Scientist

Numerical methods for the life scientist by Heino Prinz Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approxi.... Published date on: 2011-08-06 with total page: 149 pages. Publisher of Numerical Methods for the Life Scientist is Springer Science & Business Media.

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

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